Metamorphosis in amphibians is orchestrated by precise hormonal changes, with thyroid hormones playing the central role. These hormones regulate the transition from swimming, gill-breathing larvae to air-breathing, land-adapted adults by triggering widespread physiological and morphological transformations.
  • Thyroid hormones (thyroxine T4 and triiodothyronine T3) are secreted by the thyroid gland and control metamorphosis.
  • Rising thyroid hormone levels initiate larval tissue degeneration (e.g., tail resorption) and adult tissue development (e.g., lungs, limbs, vocal cords).
  • Metamorphosis timing varies but always depends on thyroid hormone regulation, linking environmental cues to developmental changes.
Thyroid hormones trigger the degeneration of larval tissues and the development of adult structures, driving metamorphosis.
Thyroid hormones (thyroxine and triiodothyronine) regulate amphibian metamorphosis.
The tail is resorbed during metamorphosis as larval tissues are broken down.

Thyroid Hormones: The Drivers of Metamorphosis

Thyroid hormones stimulate adult organ development, promote larval tissue resorption, and coordinate morphological changes.
Thyroxine (T4) and Triiodothyronine (T3) levels rise to initiate metamorphosis.
Thyroid hormone levels peak during the active phase of tissue remodeling (metamorphosis).
Thyroid hormones cause larval tissue degeneration and stimulate adult tissue growth.
The thyroid gland produces the hormones driving metamorphosis.

Metamorphosis as a Hormonal Cascade

Metamorphosis is initiated when the pituitary gland releases thyroid-stimulating hormone (TSH), prompting the thyroid gland to secrete thyroid hormones. These hormones then trigger both the degeneration of larval structures (e.g., tail, gills) and the development of adult features (e.g., lungs, limbs, skin).
  • The hormonal cascade ensures metamorphosis occurs only when environmental and internal conditions are favorable.
  • Other hormones, like corticosteroids, may assist by helping tissues adapt to new functions and regulating metabolism.
Metamorphosis begins when the pituitary gland releases TSH, stimulating the thyroid to produce hormones.
TSH from the pituitary gland triggers thyroid hormone release.
The hormonal cascade causes tissue resorption, adult organ development, and metabolic reorganization.
Hormonal release is regulated by environmental cues, ensuring proper timing.
Corticosteroids and growth hormone also influence metamorphosis.

Conclusion

Hormonal changes, especially the rise in thyroid hormones, are essential for amphibian metamorphosis, coordinating the transformation from aquatic larvae to terrestrial adults.
  • Thyroid hormones trigger both the breakdown of larval structures and the formation of adult tissues.
  • A hormonal cascade ensures metamorphosis occurs at the right time, responding to environmental signals.